April 9, 2019

The FLOW (FLuoxetine to Open the critical time period Window to improve motor recovery after stroke) trial is now recruiting at seven sites across Canada (with an eighth in Winnipeg opening soon). The study is led by Dr. Mark Bayley of Toronto Rehabilitation Institute and Dr. Janice Eng of the University of British Columbia.

The study aims to recruit 20-25 patients at each site (see map, above) to test a combination therapy to improve lower-limb motor recovery. This is the first study to use the new national stroke recovery clinical trials infrastructure developed with funding from CPSR and Brain Canada. Participants in the double-blinded randomized controlled study will get either fluoxetine (Prozac) or a placebo coupled with three doses a week of a targeted exercise program over a three- to four-month period. Fluoxetine has been shown in animal models to keep open the period of neuroplasticity that coincides with stroke recovery. The trial rationale is that motor function will be significantly improved by pairing fluoxetine with a task-based exercise program in humans. Study sites are looking to recruit patients who are less than 12 months post-stroke, are experiencing lower limb difficulties and who do not have a clinical diagnosis of depression. The primary goal of the study is to improve walking, gait and balance.

If you have questions or are interested in participating in the trial, contact Josie Chundamala, FLOW Trial Project Manager, Tel: 416-597-3422 ext. 7229 Email: josie.chundamala@uhn.ca

You can also read more on the trial at: https://clinicaltrials.gov/ct2/show/NCT03448159


Spread the word: A list of CPSR-funded trials to share with colleagues and patients:

FLOW Trial: FLuoxetine to Open the critical period time Window to improve motor recovery after stroke
Study Objective:
 To determine if Fluoxetine paired with structured exercise can improve leg function following stroke. 
Click for more information: FLOW Trial

Adaptive clothing for persons living with hemiparesis
Study Objective: 
To use a Participatory Design research methodology to engage working age women with chronic hemiparesis to create and evaluate clothing designs for outerwear, innerwear and brassieres.
Click for more information: ShahaniM – Clothing Adaptation
Click to read the recruitment poster: ShahaniM – Clothing Ad

Brain Stimulation and Tailored Interventions to Promote Recovery in Stroke Survivors 
Study Objective:
 To determine whether tailored strength training interventions in stroke survivors, based on MEPs amplitude, can lead to greater gains in arm function and to determine whether combining anodal tDCS with tailored strength training can promote recovery in stroke survivors when compared to sham tDCS.
Click for more information: TremblayF – Brain Stim Stroke Recovery

Cognitive Changes and Rehabilitation in People With Transient Ischemic Attack, Stroke, or Stroke Risk Factors
Study Objective:
 Through this study, we hope to 1) improve assessment of iWMD injury effects through behavioral assessment and multimodal brain imaging and 2) apply rehabilitation specifically for complex information processing deficits in small vessel white matter stroke.
Click for more information: LevineB – Cognitive Changes and Rehab

Computer Games for Speech Rehabilitation in Patients with Stroke
Study Objective:
 To investigate the effect of a novel game-based treatment approach on speech recovery post stroke.
Click for more information: YunusovaY – Speech Rehab

Digital technology to support informal caregivers: matching the tools to the needs from a sex and gender perspective
Study Objective:
We aim to better understand the needs and preferences of caregivers when it comes to digital technologies. Information gained from the study will enable the development of a sex- and gender- sensitive framework to support the creation and evaluation of technologies to assist with caregiving. 
Click for more information: ColantonioA – Caregiving Study
Dance for the improvement of balance and gait after stroke: A randomized controlled trial        
Study Objective:
 The objective of our project is to learn about the effects of a 12 week dance program on walking, balance and social isolation in people with chronic stroke (>6months).
Click for more information: PattersonK – Dance Study

Finger Robot Study
Study Objective:
 To learn how to improve our assistive device to make it useful and easy to use during therapy and daily life.
Click for more information: MihailidisA YurkewichA – Finger Robot Study

Monitoring functional hand use in stroke survivors using wearable technology
Study Objective: 
This study is investigating wearable technology to measure hand use at home after stroke. Participants will use a wearable camera to record how they are using their hands in selected activities of daily living, in a lab setting and at home. We will develop computer algorithms to automatically analyze hand function from these videos. We will also assess their arm and hand function with existing clinical measures. 
Click for more information: ZariffaJ – Hand Use Wearables Study

The relationship of rhythm abilities and gait after stroke
Study Objective:
 To describe the relationship between rhythm abilities and the ability to walk with a regular pattern, and also to self‐evaluate the walking pattern after stroke. The other aim of this study is to describe brain activity when performing rhythm tests.
Click for more information: PattersonK – Rhythm and gait

Therapeutic Instrumental Music Performance with Sensory-Enhanced Motor Imagery in Chronic Post-Stroke Rehabilitation
Study Objective:
 To investigate the effects of therapeutic instrumental music performance (TIMP) and sensory-enhanced motor imagery (SEMI) on upper limb movement, affect and cognition following a stroke.
Click for more information: ThautM HaireC – TIMP SEMI